Seronegative Rheumatoid Arthritis

One of the forms of arthritis that gives doctors difficulty in diagnosis is seronegative rheumatoid arthritis.

This disease is actually a collection of different forms of arthritis that have symptoms that are similar to rheumatoid arthritis. This similarity is what makes the different forms of seronegative arthritis sometimes be misdiagnosed as rheumatoid arthritis, but there are distinct differences between them.

The main difference, and the reason for the name “seronegative” is that those with rheumatoid arthritis are found to have the autoantibody called rheumatoid factor, while those with seronegative arthritis are found not to have this autoantibody. This, combined with an analysis of the different symptoms, can lead to a proper diagnosis of whether the form of arthritis present in an individual is rheumatoid arthritis, or one of the types of seronegative arthritis.

 As previously mentioned, there are different forms of seronegative arthritis, and each of these forms affect different areas of the body. As with rheumatoid arthritis, seronegative arthritis does not only attack the joints, but also different organs of the body, which again is one reason that the two can often be confused with each other. 

Examples of this disorder include but are not limited to: psoriatic arthritis, Reiter’s syndrome or reactive arthritis, and ankylosing spondylitis.

Psoriatic arthritis is a result of psoriasis, which is a chronic skin condition. Up to thirty percent of those with psoriasis will eventually develop psioriatic arthritis about ten years after developing psoriasis. This form of arthritis is inflammatory in nature, and has five different types, which can further complicate diagnosis




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